Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice

This study investigated the function of each of the hypoxia inducible factor (HIF) prolyl-4-hydroxylase enzymes (PHD1–3) in the first 24 h following transient focal cerebral ischaemia by using mice with each isoform genetically suppressed. Male, 8- to 12-week old PHD1(−/−), PHD2(+/−) and PHD3(−/−) m...

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Autores principales: Chen, Ruo-Li, Nagel, Simon, Papadakis, Michalis, Bishop, Tammie, Pollard, Patrick, Ratcliffe, Peter J, Pugh, Christopher W, Buchan, Alastair M
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2012
Materias:
Neuroscience: Neurobiology of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476649/
https://ncbi.nlm.nih.gov/pubmed/22615432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.232884
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