Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats

Dimethyloxalylglycine (DMOG) is an inhibitor of prolyl-4-hydroxylase domain (PHD) enzymes that regulate the stability of hypoxia-inducible factor (HIF). We investigated the effect of DMOG on the outcome after permanent and transient middle cerebral artery occlusion (p/tMCAO) in the rat. Before and a...

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Autors principals: Nagel, Simon, Papadakis, Michalis, Chen, Ruoli, Hoyte, Lisa C, Brooks, Keith J, Gallichan, Daniel, Sibson, Nicola R, Pugh, Chris, Buchan, Alastair M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049478/
https://ncbi.nlm.nih.gov/pubmed/20407463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.60
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