Human Oxygenase Variants Employing a Single Protein Fe(II) Ligand Are Catalytically Active

Aspartate/asparagine‐β‐hydroxylase (AspH) is a human 2‐oxoglutarate (2OG) and Fe(II) oxygenase that catalyses C3 hydroxylations of aspartate/asparagine residues of epidermal growth factor‐like domains (EGFDs). Unusually, AspH employs two histidine residues to chelate Fe(II) rather than the typical t...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Brasnett, Amelia, Pfeffer, Inga, Brewitz, Lennart, Chowdhury, Rasheduzzaman, Nakashima, Yu, Tumber, Anthony, McDonough, Michael A., Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252765/
https://ncbi.nlm.nih.gov/pubmed/33887099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202103711
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