Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

Plant homeodomain (PHD) containing proteins are important epigenetic regulators and are of interest as potential drug targets. Inspired by the amiodarone derivatives reported to inhibit the PHD finger 3 of KDM5A (KDM5A(PHD3)), a set of compounds were synthesised. Amiodarone and its derivatives were...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Bhushan, Bhaskar, Erdmann, Alexandre, Zhang, Yijia, Belle, Roman, Johannson, Catrine, Oppermann, Udo, Hopkinson, Richard J., Schofield, Christopher J., Kawamura, Akane
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380468/
https://ncbi.nlm.nih.gov/pubmed/29764755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.03.030
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