Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

Plant homeodomain (PHD) containing proteins are important epigenetic regulators and are of interest as potential drug targets. Inspired by the amiodarone derivatives reported to inhibit the PHD finger 3 of KDM5A (KDM5A(PHD3)), a set of compounds were synthesised. Amiodarone and its derivatives were...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem
Main Authors: Bhushan, Bhaskar, Erdmann, Alexandre, Zhang, Yijia, Belle, Roman, Johannson, Catrine, Oppermann, Udo, Hopkinson, Richard J., Schofield, Christopher J., Kawamura, Akane
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Science 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380468/
https://ncbi.nlm.nih.gov/pubmed/29764755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.03.030
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