Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

Plant homeodomain (PHD) containing proteins are important epigenetic regulators and are of interest as potential drug targets. Inspired by the amiodarone derivatives reported to inhibit the PHD finger 3 of KDM5A (KDM5A(PHD3)), a set of compounds were synthesised. Amiodarone and its derivatives were...

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Published in:Bioorg Med Chem
Main Authors: Bhushan, Bhaskar, Erdmann, Alexandre, Zhang, Yijia, Belle, Roman, Johannson, Catrine, Oppermann, Udo, Hopkinson, Richard J., Schofield, Christopher J., Kawamura, Akane
Format: Artigo
Language:Inglês
Published: Elsevier Science 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380468/
https://ncbi.nlm.nih.gov/pubmed/29764755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.03.030
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