Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

Plant homeodomain (PHD) containing proteins are important epigenetic regulators and are of interest as potential drug targets. Inspired by the amiodarone derivatives reported to inhibit the PHD finger 3 of KDM5A (KDM5A(PHD3)), a set of compounds were synthesised. Amiodarone and its derivatives were...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Bioorg Med Chem
Egile Nagusiak: Bhushan, Bhaskar, Erdmann, Alexandre, Zhang, Yijia, Belle, Roman, Johannson, Catrine, Oppermann, Udo, Hopkinson, Richard J., Schofield, Christopher J., Kawamura, Akane
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier Science 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380468/
https://ncbi.nlm.nih.gov/pubmed/29764755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.03.030
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