The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins

Tick chemokine-binding proteins (evasins) are an emerging class of biologicals that target multiple chemokines and show anti-inflammatory activities in preclinical disease models. Using yeast surface display, we identified a CCL8-binding evasin, P672, from the tick Rhipicephalus pulchellus. We found...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Eaton, James R. O., Alenazi, Yara, Singh, Kamayani, Davies, Graham, Geis-Asteggiante, Lucia, Kessler, Benedikt, Robinson, Carol V., Kawamura, Akane, Bhattacharya, Shoumo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912465/
https://ncbi.nlm.nih.gov/pubmed/29487134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000487
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