A knottin scaffold directs the CXC-chemokine–binding specificity of tick evasins

Tick evasins (EVAs) bind either CC- or CXC-chemokines by a poorly understood promiscuous or “one-to-many” mechanism to neutralize inflammation. Because EVAs potently inhibit inflammation in many preclinical models, highlighting their potential as biological therapeutics for inflammatory diseases, we...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Lee, Angela W., Deruaz, Maud, Lynch, Christopher, Davies, Graham, Singh, Kamayani, Alenazi, Yara, Eaton, James R. O., Kawamura, Akane, Shaw, Jeffrey, Proudfoot, Amanda E. I., Dias, João M., Bhattacharya, Shoumo
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6643034/
https://ncbi.nlm.nih.gov/pubmed/31167786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008817
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires