A knottin scaffold directs the CXC-chemokine–binding specificity of tick evasins

Tick evasins (EVAs) bind either CC- or CXC-chemokines by a poorly understood promiscuous or “one-to-many” mechanism to neutralize inflammation. Because EVAs potently inhibit inflammation in many preclinical models, highlighting their potential as biological therapeutics for inflammatory diseases, we...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Lee, Angela W., Deruaz, Maud, Lynch, Christopher, Davies, Graham, Singh, Kamayani, Alenazi, Yara, Eaton, James R. O., Kawamura, Akane, Shaw, Jeffrey, Proudfoot, Amanda E. I., Dias, João M., Bhattacharya, Shoumo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6643034/
https://ncbi.nlm.nih.gov/pubmed/31167786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008817
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