Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

Protein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by selectively dephosphorylating their substrates. Here we present 22 human PTP crystal structures that, together with prior structural knowledge, enable a comprehensive analysis of the classical PTP family. D...

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Detalhes bibliográficos
Main Authors: Barr, Alastair J., Ugochukwu, Emilie, Lee, Wen Hwa, King, Oliver N.F., Filippakopoulos, Panagis, Alfano, Ivan, Savitsky, Pavel, Burgess-Brown, Nicola A., Müller, Susanne, Knapp, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638020/
https://ncbi.nlm.nih.gov/pubmed/19167335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.11.038
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