Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1

由 Zhang, Ning, Gordon, Sarah L., Fritsch, Maximilian J., Esoof, Noor, Campbell, David G., Gourlay, Robert, Velupillai, Srikannathasan, Macartney, Thomas, Peggie, Mark, van Aalten, Daan M.F., Cousin, Michael A., Alessi, Dario R.
發表在 J Neurosci (2015)

Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors

由 Korczynska, Magdalena, Le, Daniel D., Younger, Noah, Gregori-Puigjané, Elisabet, Tumber, Anthony, Krojer, Tobias, Velupillai, Srikannathasan, Gileadi, Carina, Nowak, Radosław P., Iwasa, Eriko, Pollock, Samuel B., Torres, Idelisse Ortiz, Oppermann, Udo, Shoichet, Brian K., Fujimori, Danica Galonić
發表在 J Med Chem (2015)

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

由 Vazquez‐Rodriguez, Saleta, Wright, Miranda, Rogers, Catherine M., Cribbs, Adam P., Velupillai, Srikannathasan, Philpott, Martin, Lee, Henry, Dunford, James E., Huber, Kilian V. M., Robers, Matthew B., Vasta, James D., Thezenas, Marie‐Laetitia, Bonham, Sarah, Kessler, Benedikt, Bennett, James, Fedorov, Oleg, Raynaud, Florence, Donovan, Adam, Blagg, Julian, Bavetsias, Vassilios, Oppermann, Udo, Bountra, Chas, Kawamura, Akane, Brennan, Paul E.
發表在 Angew Chem Int Ed Engl (2018)

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

由 Tumber, Anthony, Nuzzi, Andrea, Hookway, Edward S., Hatch, Stephanie B., Velupillai, Srikannathasan, Johansson, Catrine, Kawamura, Akane, Savitsky, Pavel, Yapp, Clarence, Szykowska, Aleksandra, Wu, Na, Bountra, Chas, Strain-Damerell, Claire, Burgess-Brown, Nicola A., Ruda, Gian Filippo, Fedorov, Oleg, Munro, Shonagh, England, Katherine S., Nowak, Radoslaw P., Schofield, Christopher J., La Thangue, Nicholas B., Pawlyn, Charlotte, Davies, Faith, Morgan, Gareth, Athanasou, Nick, Müller, Susanne, Oppermann, Udo, Brennan, Paul E.
發表在 Cell Chem Biol (2017)

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (K...

由 Le Bihan, Yann-Vaï, Lanigan, Rachel M., Atrash, Butrus, McLaughlin, Mark G., Velupillai, Srikannathasan, Malcolm, Andrew G., England, Katherine S., Ruda, Gian Filippo, Mok, N. Yi, Tumber, Anthony, Tomlin, Kathy, Saville, Harry, Shehu, Erald, McAndrew, Craig, Carmichael, LeAnne, Bennett, James M., Jeganathan, Fiona, Eve, Paul, Donovan, Adam, Hayes, Angela, Wood, Francesca, Raynaud, Florence I., Fedorov, Oleg, Brennan, Paul E., Burke, Rosemary, van Montfort, Rob L.M., Rossanese, Olivia W., Blagg, Julian, Bavetsias, Vassilios
發表在 Eur J Med Chem (2019)

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

由 Resnick, Efrat, Bradley, Anthony, Gan, Jinrui, Douangamath, Alice, Krojer, Tobias, Sethi, Ritika, Geurink, Paul P., Aimon, Anthony, Amitai, Gabriel, Bellini, Dom, Bennett, James, Fairhead, Michael, Fedorov, Oleg, Gabizon, Ronen, Gan, Jin, Guo, Jingxu, Plotnikov, Alexander, Reznik, Nava, Ruda, Gian Filippo, Díaz-Sáez, Laura, Straub, Verena M., Szommer, Tamas, Velupillai, Srikannathasan, Zaidman, Daniel, Zhang, Yanling, Coker, Alun R., Dowson, Christopher G., Barr, Haim M., Wang, Chu, Huber, Kilian V.M., Brennan, Paul E., Ovaa, Huib, von Delft, Frank, London, Nir
發表在 J Am Chem Soc (2019)

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

由 Bavetsias, Vassilios, Lanigan, Rachel M., Ruda, Gian Filippo, Atrash, Butrus, McLaughlin, Mark G., Tumber, Anthony, Mok, N. Yi, Le Bihan, Yann-Vaï, Dempster, Sally, Boxall, Katherine J., Jeganathan, Fiona, Hatch, Stephanie B., Savitsky, Pavel, Velupillai, Srikannathasan, Krojer, Tobias, England, Katherine S., Sejberg, Jimmy, Thai, Ching, Donovan, Adam, Pal, Akos, Scozzafava, Giuseppe, Bennett, James M., Kawamura, Akane, Johansson, Catrine, Szykowska, Aleksandra, Gileadi, Carina, Burgess-Brown, Nicola A., von Delft, Frank, Oppermann, Udo, Walters, Zoe, Shipley, Janet, Raynaud, Florence I., Westaway, Susan M., Prinjha, Rab K., Fedorov, Oleg, Burke, Rosemary, Schofield, Christopher J., Westwood, Isaac M., Bountra, Chas, Müller, Susanne, van Montfort, Rob L. M., Brennan, Paul E., Blagg, Julian
發表在 J Med Chem (2016)