Synthesis of a benzoxazinthione derivative of tanaproget and pharmacological evaluation for PET imaging of PR expression

بواسطة Allott, Louis, Miranda, Cecilia, Hayes, Angela, Raynaud, Florence, Cawthorne, Christopher, Smith, Graham
الحاوية / القاعدة EJNMMI Radiopharm Chem (2019)

Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds

بواسطة Canning, Peter, Bataille, Carole, Bery, Nicolas, Milhas, Sabine, Hayes, Angela, Raynaud, Florence, Miller, Ami, Rabbitts, Terry
الحاوية / القاعدة J Immunol Methods (2021)

A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2

بواسطة Bery, Nicolas, Bataille, Carole J.R., Russell, Angela, Hayes, Angela, Raynaud, Florence, Milhas, Sabine, Anand, Sneha, Tulmin, Hanna, Miller, Ami, Rabbitts, Terence H.
الحاوية / القاعدة Sci Adv (2021)

Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species

بواسطة Wood, Francesca L., Shepherd, Sam, Hayes, Angela, Liu, Manjuan, Grira, Katia, Mok, Yi, Atrash, Butrus, Faisal, Amir, Bavetsias, Vassilios, Linardopoulos, Spiros, Blagg, Julian, Raynaud, Florence I.
الحاوية / القاعدة Eur J Pharm Sci (2019)

Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution

بواسطة Hayes, Angela, Mok, N. Yi, Liu, Manjuan, Thai, Ching, Henley, Alan T., Atrash, Butrus, Lanigan, Rachel M., Sejberg, Jimmy, Le Bihan, Yann-Vaï, Bavetsias, Vassilios, Blagg, Julian, Raynaud, Florence I.
الحاوية / القاعدة Xenobiotica (2016)

Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases

بواسطة Zhang, Chi, Stockwell, Simon R., Elbanna, May, Ketteler, Robin, Freeman, Jamie, Al-Lazikani, Bissan, Eccles, Suzanne, De Haven Brandon, Alexis, Raynaud, Florence, Hayes, Angela, Clarke, Paul A., Workman, Paul, Mittnacht, Sibylle
الحاوية / القاعدة Oncogene (2019)

Correction: Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases

بواسطة Zhang, Chi, Stockwell, Simon R., Elbanna, May, Ketteler, Robin, Freeman, Jamie, Al-Lazikani, Bissan, Eccles, Suzanne, De Haven Brandon, Alexis, Raynaud, Florence, Hayes, Angela, Clarke, Paul A., Workman, Paul, Mittnacht, Sibylle
الحاوية / القاعدة Oncogene (2020)

A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity

بواسطة Kostaras, Eleftherios, Kaserer, Teresa, Lazaro, Glorianne, Heuss, Sara Farrah, Hussain, Aasia, Casado, Pedro, Hayes, Angela, Yandim, Cihangir, Palaskas, Nicolaos, Yu, Yi, Schwartz, Brian, Raynaud, Florence, Chung, Yuen-Li, Cutillas, Pedro R., Vivanco, Igor
الحاوية / القاعدة Br J Cancer (2020)

Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

بواسطة Drouin, Ludovic, McGrath, Sally, Vidler, Lewis R., Chaikuad, Apirat, Monteiro, Octovia, Tallant, Cynthia, Philpott, Martin, Rogers, Catherine, Fedorov, Oleg, Liu, Manjuan, Akhtar, Wasim, Hayes, Angela, Raynaud, Florence, Müller, Susanne, Knapp, Stefan, Hoelder, Swen
الحاوية / القاعدة J Med Chem (2015)

Discovery of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors

بواسطة Lainchbury, Michael, Matthews, Thomas P., McHardy, Tatiana, Boxall, Kathy J., Walton, Michael I., Eve, Paul D., Hayes, Angela, Valenti, Melanie R., de Haven Brandon, Alexis K., Box, Gary, Aherne, G. Wynne, Reader, John C., Raynaud, Florence I., Eccles, Suzanne A., Garrett, Michelle D., Collins, Ian
منشور في 2012

HG-67 PRECLINICAL EFFICACY OF ALK2 INHIBITORS IN ACVR1 MUTANT DIPG

بواسطة Carvalho, Diana, Taylor, Kathryn, Olaciregui, Nagore G., Valenti, Melanie, Ruddle, Ruth, Henley, Alan, Hayes, Angela, Brandon, Alexis De Haven, Hallsworth, Albert, Mackay, Alan, Molinari, Valeria, Vinci, Maria, Popov, Sergey, Boudhar, Aicha, Brennan, Paul, Moore, Andrew, Hudson, Liam, Hoelder, Swen, Bullock, Alex, Raynaud, Florence, Eccles, Sue, Carcaboso, Angel M., Jones, Chris
الحاوية / القاعدة Neuro Oncol (2016)

Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1

بواسطة Wilding, Birgit, Pasqua, A. Elisa, E. A. Chessum, Nicola, Pierrat, Olivier A., Hahner, Tamas, Tomlin, Kathy, Shehu, Erald, Burke, Rosemary, Richards, G. Meirion, Whitton, Bradleigh, Arwert, Esther N., Thapaliya, Arjun, Salimraj, Ramya, van Montfort, Rob, Skawinska, Agi, Hayes, Angela, Raynaud, Florence, Chopra, Rajesh, Jones, Keith, Newton, Gary, Cheeseman, Matthew D.
الحاوية / القاعدة Bioorg Med Chem Lett (2021)

CCT244747 is a novel, potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs

بواسطة Walton, Mike I, Eve, Paul D, Hayes, Angela, Valenti, Melanie R, De Haven Brandon, Alexis K, Box, Gary, Hallsworth, Albert, Smith, Elizabeth L, Boxall, Kathy J, Lainchbury, Michael, Matthews, Thomas P, Jamin, Yann, Robinson, Simon P, Aherne, G Wynne, Reader, John C, Chesler, Louis, Raynaud, Florence I, Eccles, Suzanne A, Collins, Ian, Garrett, Michelle D
منشور في 2012

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

بواسطة Raynaud, Florence I., Eccles, Suzanne A., Patel, Sonal, Alix, Sonia, Box, Gary, Chuckowree, Irina, Folkes, Adrian, Gowan, Sharon, De Haven Brandon, Alexis, Di Stefano, Francesca, Hayes, Angela, Henley, Alan T., Lensun, Letitia, Pergl-Wilson, Giles, Robson, Anthony, Saghir, Nahid, Zhyvoloup, Alexander, McDonald, Edward, Sheldrake, Peter, Shuttleworth, Stephen, Valenti, Melanie, Wan, Nan Chi, Clarke, Paul A., Workman, Paul
منشور في 2009

ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma

بواسطة Carvalho, Diana, Taylor, Kathryn R., Olaciregui, Nagore Gene, Molinari, Valeria, Clarke, Matthew, Mackay, Alan, Ruddle, Ruth, Henley, Alan, Valenti, Melanie, Hayes, Angela, Brandon, Alexis De Haven, Eccles, Suzanne A., Raynaud, Florence, Boudhar, Aicha, Monje, Michelle, Popov, Sergey, Moore, Andrew S., Mora, Jaume, Cruz, Ofelia, Vinci, Mara, Brennan, Paul E., Bullock, Alex N., Carcaboso, Angel Montero, Jones, Chris
الحاوية / القاعدة Commun Biol (2019)

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma

بواسطة Walton, Mike I., Eve, Paul D., Hayes, Angela, Henley, Alan T., Valenti, Melanie R., De Haven Brandon, Alexis K., Box, Gary, Boxall, Kathy J., Tall, Matthew, Swales, Karen, Matthews, Thomas P., McHardy, Tatiana, Lainchbury, Michael, Osborne, James, Hunter, Jill E., Perkins, Neil D., Aherne, G. Wynne, Reader, John C., Raynaud, Florence I., Eccles, Suzanne A., Collins, Ian, Garrett, Michelle D.
الحاوية / القاعدة Oncotarget (2015)

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

بواسطة Rye, Carl S., Chessum, Nicola E. A., Lamont, Scott, Pike, Kurt G., Faulder, Paul, Demeritt, Julie, Kemmitt, Paul, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew D., Isaac, Rosie, Goodwin, Louise, Boros, Joanna, Raynaud, Florence, Hayes, Angela, Henley, Alan T., de Billy, Emmanuel, Lynch, Christopher J., Sharp, Swee Y., te Poele, Robert, Fee, Lisa O’, Foote, Kevin M., Green, Stephen, Workman, Paul, Jones, Keith
الحاوية / القاعدة Medchemcomm (2016)

Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy

بواسطة Faisal, Amir, Mak, Grace W Y, Gurden, Mark D, Xavier, Cristina P R, Anderhub, Simon J, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Box, Gary, Valenti, Melanie R, De Haven Brandon, Alexis K, O'Fee, Lisa, Schmitt, Jessica, Woodward, Hannah L, Burke, Rosemary, vanMontfort, Rob L M, Blagg, Julian, Raynaud, Florence I, Eccles, Suzanne A, Hoelder, Swen, Linardopoulos, Spiros
الحاوية / القاعدة Br J Cancer (2017)

Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

بواسطة Naud, Sébastien, Westwood, Isaac M., Faisal, Amir, Sheldrake, Peter, Bavetsias, Vassilios, Atrash, Butrus, Cheung, Kwai-Ming J., Liu, Manjuan, Hayes, Angela, Schmitt, Jessica, Wood, Amy, Choi, Vanessa, Boxall, Kathy, Mak, Grace, Gurden, Mark, Valenti, Melanie, de Haven Brandon, Alexis, Henley, Alan, Baker, Ross, McAndrew, Craig, Matijssen, Berry, Burke, Rosemary, Hoelder, Swen, Eccles, Suzanne A., Raynaud, Florence I., Linardopoulos, Spiros, van Montfort, Rob L. M., Blagg, Julian
منشور في 2013

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

بواسطة Cheeseman, Matthew D., Chessum, Nicola E. A., Rye, Carl S., Pasqua, A. Elisa, Tucker, Michael J., Wilding, Birgit, Evans, Lindsay E., Lepri, Susan, Richards, Meirion, Sharp, Swee Y., Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T., Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M., Eccles, Suzanne A., Workman, Paul, Jones, Keith
الحاوية / القاعدة J Med Chem (2016)