Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

Heat shock factor 1 (HSF1) is a transcription factor that plays key roles in cancer, including providing a mechanism for cell survival under proteotoxic stress. Therefore, inhibition of the HSF1-stress pathway represents an exciting new opportunity in cancer treatment. We employed an unbiased phenot...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Rye, Carl S., Chessum, Nicola E. A., Lamont, Scott, Pike, Kurt G., Faulder, Paul, Demeritt, Julie, Kemmitt, Paul, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew D., Isaac, Rosie, Goodwin, Louise, Boros, Joanna, Raynaud, Florence, Hayes, Angela, Henley, Alan T., de Billy, Emmanuel, Lynch, Christopher J., Sharp, Swee Y., te Poele, Robert, Fee, Lisa O’, Foote, Kevin M., Green, Stephen, Workman, Paul, Jones, Keith
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048338/
https://ncbi.nlm.nih.gov/pubmed/27746890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00159a
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