Targeting the kinase activities of ATR and ATM exhibits therapeutic potential in a mouse model of MLL-rearranged AML

מאת Morgado-Palacin, Isabel, Day, Amanda, Murga, Matilde, Lafarga, Vanesa, Anton, Marta Elena, Tubbs, Anthony, Chen, Hua Tang, Ergan, Aysegul, Anderson, Rhonda, Bhandoola, Avinash, Pike, Kurt G., Barlaam, Bernard, Cadogan, Elaine, Wang, Xi, Pierce, Andrew J., Hubbard, Chad, Armstrong, Scott A., Nussenzweig, André, Fernandez-Capetillo, Oscar
הוצא לאור ב Sci Signal (2016)

Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors

מאת Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Colclough, Nicola, Dishington, Allan, Durant, Stephen, Goldberg, Kristin, Hassall, Lorraine A., Hughes, Gareth D., MacFaul, Philip A., McGuire, Thomas M., Pass, Martin, Patel, Anil, Pearson, Stuart, Petersen, Jens, Pike, Kurt G., Robb, Graeme, Stratton, Natalie, Xin, Guohong, Zhai, Baochang
הוצא לאור ב ACS Med Chem Lett (2018)

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

מאת Rye, Carl S., Chessum, Nicola E. A., Lamont, Scott, Pike, Kurt G., Faulder, Paul, Demeritt, Julie, Kemmitt, Paul, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew D., Isaac, Rosie, Goodwin, Louise, Boros, Joanna, Raynaud, Florence, Hayes, Angela, Henley, Alan T., de Billy, Emmanuel, Lynch, Christopher J., Sharp, Swee Y., te Poele, Robert, Fee, Lisa O’, Foote, Kevin M., Green, Stephen, Workman, Paul, Jones, Keith
הוצא לאור ב Medchemcomm (2016)

Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

מאת Johannes, Jeffrey W., Almeida, Lynsie, Barlaam, Bernard, Boriack-Sjodin, P. Ann, Casella, Robert, Croft, Rosemary A., Dishington, Allan P., Gingipalli, Lakshmaiah, Gu, Chungang, Hawkins, Janet L., Holmes, Jane L., Howard, Tina, Huang, Jian, Ioannidis, Stephanos, Kazmirski, Steven, Lamb, Michelle L., McGuire, Thomas M., Moore, Jane E., Ogg, Derek, Patel, Anil, Pike, Kurt G., Pontz, Timothy, Robb, Graeme R., Su, Nancy, Wang, Haiyun, Wu, Xiaoyun, Zhang, Hai-Jun, Zhang, Yue, Zheng, Xiaolan, Wang, Tao
הוצא לאור ב ACS Med Chem Lett (2015)

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

מאת Durant, Stephen T., Zheng, Li, Wang, Yingchun, Chen, Kan, Zhang, Lingli, Zhang, Tianwei, Yang, Zhenfan, Riches, Lucy, Trinidad, Antonio G., Fok, Jacqueline H. L., Hunt, Tom, Pike, Kurt G., Wilson, Joanne, Smith, Aaron, Colclough, Nicola, Reddy, Venkatesh Pilla, Sykes, Andrew, Janefeldt, Annika, Johnström, Peter, Varnäs, Katarina, Takano, Akihiro, Ling, Stephanie, Orme, Jonathan, Stott, Jonathan, Roberts, Caroline, Barrett, Ian, Jones, Gemma, Roudier, Martine, Pierce, Andrew, Allen, Jasmine, Kahn, Jenna, Sule, Amrita, Karlin, Jeremy, Cronin, Anna, Chapman, Melissa, Valerie, Kristoffer, Illingworth, Ruth, Pass, Martin
הוצא לאור ב Sci Adv (2018)

Orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice

מאת Karlin, Jeremy, Allen, Jasmine, Ahmad, Syed F., Hughes, Gareth, Sheridan, Victoria, Odedra, Rajesh, Farrington, Paul, Cadogan, Elaine B., Riches, Lucy C., Garcia-Trinidad, Antonio, Thomason, Andrew G., Patel, Bhavika, Vincent, Jennifer, Lau, Alan, Pike, Kurt G., Hunt, Thomas A., Sule, Amrita, Valerie, Nicholas C.K., Biddlestone-Thorpe, Laura, Kahn, Jenna, Beckta, Jason M., Mukhopadhyay, Nitai, Barlaam, Bernard, Degorce, Sebastien L., Kettle, Jason, Colclough, Nicola, Wilson, Joanne, Smith, Aaron, Barrett, Ian P., Zheng, Li, Zhang, Tianwei, Wang, Yingchun, Chen, Kan, Pass, Martin, Durant, Stephen T., Valerie, Kristoffer
הוצא לאור ב Mol Cancer Ther (2018)