Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1

door Rolfe, Alan, Yao, Shihua, Nguyen, Toung-Vi, Omoto, Kiyoyuki, Colombo, Federico, Virrankoski, Milena, Vaillancourt, Frédéric H., Yu, Lihua, Cook, Andrew, Reynolds, Dominic, Ioannidis, Stephanos, Zhu, Ping, Larsen, Nicholas A., Bolduc, David M.
Gepubliceerd in ACS Med Chem Lett (2020)

Discovery of Aminopyrazole Derivatives as Potent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2 and 3

door Brawn, Ryan A., Cook, Andrew, Omoto, Kiyoyuki, Ke, Jiyuan, Karr, Craig, Colombo, Federico, Virrankoski, Milena, Prajapati, Sudeep, Reynolds, Dominic, Bolduc, David M., Nguyen, Tuong-Vi, Gee, Patricia, Borrelli, Deanna, Caleb, Benjamin, Yao, Shihua, Irwin, Sean, Larsen, Nicholas A., Selvaraj, Anand, Zhao, Xuesong, Ioannidis, Stephanos
Gepubliceerd in ACS Med Chem Lett (2020)

Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors

door Wang, Tao, Lamb, Michelle L., Block, Michael H., Davies, Audrey Molina, Han, Yongxin, Hoffmann, Ethan, Ioannidis, Stephanos, Josey, John A., Liu, Zhong-Ying, Lyne, Paul D., MacIntyre, Terry, Mohr, Peter J., Omer, Charles A., Sjögren, Tove, Thress, Kenneth, Wang, Bin, Wang, Haiyun, Yu, Dingwei, Zhang, Hai-Jun
Gepubliceerd in 2012

The JAK2 Inhibitor, AZD1480, Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

door Hedvat, Michael, Huszar, Dennis, Herrmann, Andreas, Gozgit, Joseph M., Schroeder, Anne, Sheehy, Adam, Buettner, Ralf, Proia, David, Kowolik, Claudia M., Xin, Hong, Armstrong, Brian, Bebernitz, Geraldine, Weng, Shaobu, Wang, Lin, Ye, Minwei, McEachern, Kristen, Chen, Huawei, Morosini, Deborah, Bell, Kirsten, Alimzhanov, Marat, Ioannidis, Stephanos, McCoon, Patricia, Cao, Zhu A., Yu, Hua, Jove, Richard, Zinda, Michael
Gepubliceerd in 2009

The deubiquitylase USP9X controls ribosomal stalling

door Clancy, Anne, Heride, Claire, Pinto-Fernández, Adán, Elcocks, Hannah, Kallinos, Andreas, Kayser-Bricker, Katherine J., Wang, Weiping, Smith, Victoria, Davis, Simon, Fessler, Shawn, McKinnon, Crystal, Katz, Marie, Hammonds, Tim, Jones, Neil P., O’Connell, Jonathan, Follows, Bruce, Mischke, Steven, Caravella, Justin A., Ioannidis, Stephanos, Dinsmore, Christopher, Kim, Sunkyu, Behrens, Axel, Komander, David, Kessler, Benedikt M., Urbé, Sylvie, Clague, Michael J.
Gepubliceerd in J Cell Biol (2021)

Correction: The deubiquitylase USP9X controls ribosomal stalling

door Clancy, Anne, Heride, Claire, Pinto-Fernández, Adán, Elcocks, Hannah, Kallinos, Andreas, Kayser-Bricker, Katherine J., Wang, Weiping, Smith, Victoria, Davis, Simon, Fessler, Shawn, McKinnon, Crystal, Katz, Marie, Hammonds, Tim, Jones, Neil P., O'Connell, Jonathan, Follows, Bruce, Mischke, Steven, Caravella, Justin A., Ioannidis, Stephanos, Dinsmore, Christopher, Kim, Sunkyu, Behrens, Axel, Komander, David, Kessler, Benedikt M., Urbé, Sylvie, Clague, Michael J.
Gepubliceerd in J Cell Biol (2021)

USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

door Rusilowicz-Jones, Emma V, Jardine, Jane, Kallinos, Andreas, Pinto-Fernandez, Adan, Guenther, Franziska, Giurrandino, Mariacarmela, Barone, Francesco G, McCarron, Katy, Burke, Christopher J, Murad, Alejandro, Martinez, Aitor, Marcassa, Elena, Gersch, Malte, Buckmelter, Alexandre J, Kayser-Bricker, Katherine J, Lamoliatte, Frederic, Gajbhiye, Akshada, Davis, Simon, Scott, Hannah C, Murphy, Emma, England, Katherine, Mortiboys, Heather, Komander, David, Trost, Matthias, Kessler, Benedikt M, Ioannidis, Stephanos, Ahlijanian, Michael K, Urbé, Sylvie, Clague, Michael J
Gepubliceerd in Life Sci Alliance (2020)

Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

door Johannes, Jeffrey W., Almeida, Lynsie, Barlaam, Bernard, Boriack-Sjodin, P. Ann, Casella, Robert, Croft, Rosemary A., Dishington, Allan P., Gingipalli, Lakshmaiah, Gu, Chungang, Hawkins, Janet L., Holmes, Jane L., Howard, Tina, Huang, Jian, Ioannidis, Stephanos, Kazmirski, Steven, Lamb, Michelle L., McGuire, Thomas M., Moore, Jane E., Ogg, Derek, Patel, Anil, Pike, Kurt G., Pontz, Timothy, Robb, Graeme R., Su, Nancy, Wang, Haiyun, Wu, Xiaoyun, Zhang, Hai-Jun, Zhang, Yue, Zheng, Xiaolan, Wang, Tao
Gepubliceerd in ACS Med Chem Lett (2015)

Molecular basis of USP7 inhibition by selective small molecule inhibitors

door Turnbull, Andrew P., Ioannidis, Stephanos, Krajewski, Wojciech W., Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C.L., Tonkin, Louise M., Townsend, Elizabeth C., Buker, Shane M., Lancia, David R., Caravella, Justin A., Toms, Angela V., Charlton, Thomas M., Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C., Evans, Nicola J., Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V., Talbot, Adam C., Buckmelter, Alexandre J., Wang, Minghua, McKinnon, Crystal L., Saab, Fabienne, McGouran, Joanna F., Century, Hannah, Gersch, Malte, Pittman, Marc S., Marshall, C. Gary, Raynham, Tony M., Simcox, Mary, Stewart, Lorna M.D., McLoughlin, Sheila B., Escobedo, Jaime A., Bair, Kenneth W., Dinsmore, Christopher J., Hammonds, Tim R., Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J., Kessler, Benedikt M., Komander, David
Gepubliceerd in Nature (2017)