Molecular basis of USP7 inhibition by selective small molecule inhibitors

Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases (DUBs) remove ubiquitin from proteins, and their inhibition can induce degradation of select proteins, potentially including otherwise ‘undruggable’ t...

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Wydane w:Nature
Główni autorzy: Turnbull, Andrew P., Ioannidis, Stephanos, Krajewski, Wojciech W., Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C.L., Tonkin, Louise M., Townsend, Elizabeth C., Buker, Shane M., Lancia, David R., Caravella, Justin A., Toms, Angela V., Charlton, Thomas M., Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C., Evans, Nicola J., Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V., Talbot, Adam C., Buckmelter, Alexandre J., Wang, Minghua, McKinnon, Crystal L., Saab, Fabienne, McGouran, Joanna F., Century, Hannah, Gersch, Malte, Pittman, Marc S., Marshall, C. Gary, Raynham, Tony M., Simcox, Mary, Stewart, Lorna M.D., McLoughlin, Sheila B., Escobedo, Jaime A., Bair, Kenneth W., Dinsmore, Christopher J., Hammonds, Tim R., Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J., Kessler, Benedikt M., Komander, David
Format: Artigo
Język:Inglês
Wydane: 2017
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6029662/
https://ncbi.nlm.nih.gov/pubmed/29045389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24451
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