Structure of nicastrin unveils secrets of γ-secretase

Por Bolduc, David M., Wolfe, Michael S.
Publicado em 2014

Enzymatic assays for studying intramembrane proteolysis

Por Bolduc, David M., Selkoe, Dennis J., Wolfe, Michael S.
Publicado no Methods Enzymol (2016)

Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain

Por Bolduc, David M., Montagna, Daniel R., Gu, Yongli, Selkoe, Dennis J., Wolfe, Michael S.
Publicado no Proc Natl Acad Sci U S A (2016)

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

Por Bolduc, David M, Montagna, Daniel R, Seghers, Matthew C, Wolfe, Michael S, Selkoe, Dennis J
Publicado no eLife (2016)

Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation

Por Chen, Zan, Dempsey, Daniel R., Thomas, Stefani N., Hayward, Dawn, Bolduc, David M., Cole, Philip A.
Publicado no J Biol Chem (2016)

Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases

Por Chen, Zan, Thomas, Stefani N., Bolduc, David M., Jiang, Xuejun, Zhang, Xiangbin, Wolberger, Cynthia, Cole, Philip A.
Publicado no Biochemistry (2016)

Structural basis of nSH2 regulation and lipid binding in PI3Kα

Por Miller, Michelle S., Schmidt-Kittler, Oleg, Bolduc, David M., Brower, Evan T., Chaves-Moreira, Daniele, Allaire, Marc, Kinzler, Kenneth W., Jennings, Ian G., Thompson, Philip E., Cole, Philip A., Amzel, L. Mario, Vogelstein, Bert, Gabelli, Sandra B.
Publicado em 2014