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The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
γ-secretase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-prone amyloid-beta (Aβ) peptides, which are centrally implicated in the pathogenesis of Alzheimer’s disease (AD). Despite considerable interest in developing γ-secretase targeting therapeutics f...
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| Gepubliceerd in: | eLife |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
eLife Sciences Publications, Ltd
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5134833/ https://ncbi.nlm.nih.gov/pubmed/27580372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17578 |
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