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Toward structural elucidation of the γ-secretase complex

γ-Secretase is an intramembrane protease complex that mediates the Notch signaling pathway and the production of amyloid β-proteins. As such, this enzyme has emerged as an important target for development of novel therapeutics for Alzheimer disease and cancer. Great progress has been made in the ide...

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Detalhes bibliográficos
Main Authors: Li, Huilin, Wolfe, Michael S., Selkoe, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661031/
https://ncbi.nlm.nih.gov/pubmed/19278647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.01.007
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