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Toward structural elucidation of the γ-secretase complex
γ-Secretase is an intramembrane protease complex that mediates the Notch signaling pathway and the production of amyloid β-proteins. As such, this enzyme has emerged as an important target for development of novel therapeutics for Alzheimer disease and cancer. Great progress has been made in the ide...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2661031/ https://ncbi.nlm.nih.gov/pubmed/19278647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.01.007 |
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