Cryo-Electron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

γ-Secretase, an integral membrane protein complex, catalyzes the intramembrane cleavage of the β-amyloid precursor protein (APP) during the neuronal production of the amyloid β-peptide (Aβ). As such, the protease has emerged as a key target for developing agents to treat and prevent Alzheimer's...

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Main Authors: Osenkowski, Pamela, Li, Hua, Ye, Wenjuan, Li, Dongyang, Aeschbach, Lorene, Fraering, Patrick C., Wolfe, Michael S., Selkoe, Dennis J., Li, Huilin
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830092/
https://ncbi.nlm.nih.gov/pubmed/19013469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.10.078
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