Cryo-Electron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

γ-Secretase, an integral membrane protein complex, catalyzes the intramembrane cleavage of the β-amyloid precursor protein (APP) during the neuronal production of the amyloid β-peptide (Aβ). As such, the protease has emerged as a key target for developing agents to treat and prevent Alzheimer's...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Osenkowski, Pamela, Li, Hua, Ye, Wenjuan, Li, Dongyang, Aeschbach, Lorene, Fraering, Patrick C., Wolfe, Michael S., Selkoe, Dennis J., Li, Huilin
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830092/
https://ncbi.nlm.nih.gov/pubmed/19013469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.10.078
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы