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The effects of membrane lipids on the activity and processivity of purified γ-secretase
The 19-transmembrane multi-subunit γ-secretase complex generates the amyloid β-peptide (Aβ) of Alzheimer’s disease (AD) by intramembrane proteolysis of the β-amyloid precursor protein (APP). Despite substantial advances in elucidating how this protein complex functions, the effect of the local membr...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347702/ https://ncbi.nlm.nih.gov/pubmed/22489600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300303g |
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