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Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

γ-Secretase is an unusual and ubiquitous aspartyl protease with an intramembrane catalytic site that cleaves many type-I integral membrane proteins, most notably APP and Notch. Several reports suggest that cleavage of APP to produce the Aβ peptide is regulated in part by lipids. As γ-secretase is a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Osenkowski, Pamela, Ye, Wenjuan, Wang, Rong, Wolfe, Michael S., Selkoe, Dennis J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504869/
https://ncbi.nlm.nih.gov/pubmed/18539594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801925200
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