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Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment
γ-Secretase is an unusual and ubiquitous aspartyl protease with an intramembrane catalytic site that cleaves many type-I integral membrane proteins, most notably APP and Notch. Several reports suggest that cleavage of APP to produce the Aβ peptide is regulated in part by lipids. As γ-secretase is a...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2504869/ https://ncbi.nlm.nih.gov/pubmed/18539594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801925200 |
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