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Part 1: Notch-Sparing γ-Secretase Inhibitors: The Identification of Novel Naphthyl and Benzofuranyl Amide Analogs
γ-Secretase is one of two proteases directly involved in the production of the amyloid β-peptide, (Aβ) which is pathogenic in Alzheimer’s disease. Inhibition of γ-secretase to suppress the production of Aβ should not block processing of one of its alternative substrates, Notch1 receptors, as interfe...
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| Published in: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8317589/ https://ncbi.nlm.nih.gov/pubmed/27013392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.040 |
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