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Part 1: Notch-Sparing γ-Secretase Inhibitors: The Identification of Novel Naphthyl and Benzofuranyl Amide Analogs

γ-Secretase is one of two proteases directly involved in the production of the amyloid β-peptide, (Aβ) which is pathogenic in Alzheimer’s disease. Inhibition of γ-secretase to suppress the production of Aβ should not block processing of one of its alternative substrates, Notch1 receptors, as interfe...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Lu, Dai, Wei, Han-Xun, Zhang, Jing, Gu, Yongli, Osenkowski, Pamela, Ye, Wenjuan, Selkoe, Dennis J., Wolfe, Michael S., Augelli-Szafran, Corinne E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317589/
https://ncbi.nlm.nih.gov/pubmed/27013392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.040
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