Caricamento...

Discovery of Notch-Sparing γ-Secretase Inhibitors

Overwhelming evidence supports a central role for the amyloid β-peptide (Aβ) in the pathogenesis of Alzheimer’s disease (AD), and the proteases that produce Aβ from its precursor protein APP are top targets for therapeutic intervention. Considerable effort has focused on targeting γ-secretase, which...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Augelli-Szafran, Corinne E., Wei, Han-Xun, Lu, Dai, Zhang, Jing, Gu, Yongli, Yang, Ting, Osenkowski, Pamela, Ye, Wenjuan, Wolfe, Michael S
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858232/
https://ncbi.nlm.nih.gov/pubmed/20088802
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !