Discovery of Notch-Sparing γ-Secretase Inhibitors

Overwhelming evidence supports a central role for the amyloid β-peptide (Aβ) in the pathogenesis of Alzheimer’s disease (AD), and the proteases that produce Aβ from its precursor protein APP are top targets for therapeutic intervention. Considerable effort has focused on targeting γ-secretase, which...

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Bibliografiske detaljer
Main Authors: Augelli-Szafran, Corinne E., Wei, Han-Xun, Lu, Dai, Zhang, Jing, Gu, Yongli, Yang, Ting, Osenkowski, Pamela, Ye, Wenjuan, Wolfe, Michael S
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858232/
https://ncbi.nlm.nih.gov/pubmed/20088802
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