Part 2. Notch-Sparing γ-Secretase Inhibitors: The Study of Novel γ-Amino Naphthyl Alcohols

One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the beginning of a series of studies from our laboratories, a series of novel γ-amino alcohols (1) were found to possess γ-secretase inhibitory activity and Notc...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Wei, Han-Xun, Lu, Dai, Sun, Vivien, Zhang, Jing, Gu, Yongli, Osenkowski, Pamela, Ye, Wenjuan, Selkoe, Dennis J., Wolfe, Michael S., Augelli-Szafran, Corinne E.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323768/
https://ncbi.nlm.nih.gov/pubmed/27020305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.042
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