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Part 2. Notch-Sparing γ-Secretase Inhibitors: The Study of Novel γ-Amino Naphthyl Alcohols
One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the beginning of a series of studies from our laboratories, a series of novel γ-amino alcohols (1) were found to possess γ-secretase inhibitory activity and Notc...
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| Veröffentlicht in: | Bioorg Med Chem Lett |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8323768/ https://ncbi.nlm.nih.gov/pubmed/27020305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.042 |
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