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Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis
[Image: see text] The 19-transmembrane γ-secretase complex generates the amyloid β-peptide of Alzheimer’s disease by intramembrane proteolysis of the β-amyloid precursor protein. This complex is comprised of presenilin, Aph1, nicastrin, and Pen-2. The exact function and mechanism of the highly conse...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American
Chemical Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4216188/ https://ncbi.nlm.nih.gov/pubmed/24941111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500489j |
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