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Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase
BACKGROUND: Alcadein proteins (Alcs; Alcα, Alcβand Alcγ) are predominantly expressed in neurons, as is Alzheimer's β-amyloid (Aβ) precursor protein (APP). Both Alcs and APP are cleaved by primary α- or β-secretase to generate membrane-associated C-terminal fragments (CTFs). Alc CTFs are further...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3637299/ https://ncbi.nlm.nih.gov/pubmed/23658629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062431 |
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