Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase

BACKGROUND: Alcadein proteins (Alcs; Alcα, Alcβand Alcγ) are predominantly expressed in neurons, as is Alzheimer's β-amyloid (Aβ) precursor protein (APP). Both Alcs and APP are cleaved by primary α- or β-secretase to generate membrane-associated C-terminal fragments (CTFs). Alc CTFs are further...

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Bibliographische Detailangaben
Hauptverfasser: Piao, Yi, Kimura, Ayano, Urano, Satomi, Saito, Yuhki, Taru, Hidenori, Yamamoto, Tohru, Hata, Saori, Suzuki, Toshiharu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637299/
https://ncbi.nlm.nih.gov/pubmed/23658629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062431
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