Alcadein Cleavages by Amyloid β-Precursor Protein (APP) α- and γ-Secretases Generate Small Peptides, p3-Alcs, Indicating Alzheimer Disease-related γ-Secretase Dysfunction

Alcadeins (Alcs) constitute a family of neuronal type I membrane proteins, designated Alc(α), Alc(β), and Alc(γ). The Alcs express in neurons dominantly and largely colocalize with the Alzheimer amyloid precursor protein (APP) in the brain. Alcs and APP show an identical function as a cargo receptor...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hata, Saori, Fujishige, Sayaka, Araki, Yoichi, Kato, Naoko, Araseki, Masahiko, Nishimura, Masaki, Hartmann, Dieter, Saftig, Paul, Fahrenholz, Falk, Taniguchi, Miyako, Urakami, Katsuya, Akatsu, Hiroyasu, Martins, Ralph N., Yamamoto, Kazuo, Maeda, Masahiro, Yamamoto, Tohru, Nakaya, Tadashi, Gandy, Sam, Suzuki, Toshiharu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Protein Synthesis, Post-Translational Modification, and Degradation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794718/
https://ncbi.nlm.nih.gov/pubmed/19864413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057497
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