Alcadein Cleavages by Amyloid β-Precursor Protein (APP) α- and γ-Secretases Generate Small Peptides, p3-Alcs, Indicating Alzheimer Disease-related γ-Secretase Dysfunction

Alcadeins (Alcs) constitute a family of neuronal type I membrane proteins, designated Alc(α), Alc(β), and Alc(γ). The Alcs express in neurons dominantly and largely colocalize with the Alzheimer amyloid precursor protein (APP) in the brain. Alcs and APP show an identical function as a cargo receptor...

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Main Authors: Hata, Saori, Fujishige, Sayaka, Araki, Yoichi, Kato, Naoko, Araseki, Masahiko, Nishimura, Masaki, Hartmann, Dieter, Saftig, Paul, Fahrenholz, Falk, Taniguchi, Miyako, Urakami, Katsuya, Akatsu, Hiroyasu, Martins, Ralph N., Yamamoto, Kazuo, Maeda, Masahiro, Yamamoto, Tohru, Nakaya, Tadashi, Gandy, Sam, Suzuki, Toshiharu
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2009
נושאים:
Protein Synthesis, Post-Translational Modification, and Degradation
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794718/
https://ncbi.nlm.nih.gov/pubmed/19864413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057497
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