Alternative Processing of γ-Secretase Substrates in Common Forms of Mild Cognitive Impairment and Alzheimer's Disease: Evidence for γ-Secretase Dysfunction

OBJECTIVE: The most common pathogenesis for familial Alzheimer's disease (FAD) involves misprocessing (or alternative processing) of the amyloid precursor protein (APP) by γ-secretase due to mutations of the presenilin 1 (PS1) gene. This misprocessing/alternative processing leads to an increase...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hata, Saori, Fujishige, Sayaka, Araki, Yoichi, Taniguchi, Miyako, Urakami, Katsuya, Peskind, Elaine, Akatsu, Hiroyasu, Araseki, Masahiko, Yamamoto, Kazuo, Martins, Ralph N., Maeda, Masahiro, Nishimura, Masaki, Levey, Allan, Chung, Kathryn A., Montine, Thomas, Leverenz, James, Fagan, Anne, Goate, Alison, Bateman, Randall, Holtzman, David M., Yamamoto, Tohru, Nakaya, Tadashi, Gandy, Sam, Suzuki, Toshiharu
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306841/
https://ncbi.nlm.nih.gov/pubmed/21681798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22343
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados