Alternative Processing of γ-Secretase Substrates in Common Forms of Mild Cognitive Impairment and Alzheimer's Disease: Evidence for γ-Secretase Dysfunction

OBJECTIVE: The most common pathogenesis for familial Alzheimer's disease (FAD) involves misprocessing (or alternative processing) of the amyloid precursor protein (APP) by γ-secretase due to mutations of the presenilin 1 (PS1) gene. This misprocessing/alternative processing leads to an increase...

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Autores principales: Hata, Saori, Fujishige, Sayaka, Araki, Yoichi, Taniguchi, Miyako, Urakami, Katsuya, Peskind, Elaine, Akatsu, Hiroyasu, Araseki, Masahiko, Yamamoto, Kazuo, Martins, Ralph N., Maeda, Masahiro, Nishimura, Masaki, Levey, Allan, Chung, Kathryn A., Montine, Thomas, Leverenz, James, Fagan, Anne, Goate, Alison, Bateman, Randall, Holtzman, David M., Yamamoto, Tohru, Nakaya, Tadashi, Gandy, Sam, Suzuki, Toshiharu
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306841/
https://ncbi.nlm.nih.gov/pubmed/21681798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22343
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