Alternative Processing of γ-Secretase Substrates in Common Forms of Mild Cognitive Impairment and Alzheimer's Disease: Evidence for γ-Secretase Dysfunction

OBJECTIVE: The most common pathogenesis for familial Alzheimer's disease (FAD) involves misprocessing (or alternative processing) of the amyloid precursor protein (APP) by γ-secretase due to mutations of the presenilin 1 (PS1) gene. This misprocessing/alternative processing leads to an increase...

詳細記述

保存先:
書誌詳細
主要な著者: Hata, Saori, Fujishige, Sayaka, Araki, Yoichi, Taniguchi, Miyako, Urakami, Katsuya, Peskind, Elaine, Akatsu, Hiroyasu, Araseki, Masahiko, Yamamoto, Kazuo, Martins, Ralph N., Maeda, Masahiro, Nishimura, Masaki, Levey, Allan, Chung, Kathryn A., Montine, Thomas, Leverenz, James, Fagan, Anne, Goate, Alison, Bateman, Randall, Holtzman, David M., Yamamoto, Tohru, Nakaya, Tadashi, Gandy, Sam, Suzuki, Toshiharu
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306841/
https://ncbi.nlm.nih.gov/pubmed/21681798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22343
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料