Alternative Processing of γ-Secretase Substrates in Common Forms of Mild Cognitive Impairment and Alzheimer's Disease: Evidence for γ-Secretase Dysfunction

OBJECTIVE: The most common pathogenesis for familial Alzheimer's disease (FAD) involves misprocessing (or alternative processing) of the amyloid precursor protein (APP) by γ-secretase due to mutations of the presenilin 1 (PS1) gene. This misprocessing/alternative processing leads to an increase...

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Main Authors: Hata, Saori, Fujishige, Sayaka, Araki, Yoichi, Taniguchi, Miyako, Urakami, Katsuya, Peskind, Elaine, Akatsu, Hiroyasu, Araseki, Masahiko, Yamamoto, Kazuo, Martins, Ralph N., Maeda, Masahiro, Nishimura, Masaki, Levey, Allan, Chung, Kathryn A., Montine, Thomas, Leverenz, James, Fagan, Anne, Goate, Alison, Bateman, Randall, Holtzman, David M., Yamamoto, Tohru, Nakaya, Tadashi, Gandy, Sam, Suzuki, Toshiharu
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306841/
https://ncbi.nlm.nih.gov/pubmed/21681798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22343
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