Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects

BACKGROUND: Alcadein(α) (Alc(α)) is a neuronal membrane protein that colocalizes with the Alzheimer's amyloid-β precursor protein (APP). Successive cleavage of APP by β- and γ-secretases generates the aggregatable amyloid-β peptide (Aβ), while cleavage of APP or Alc(α) by α- and γ-secretases ge...

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Détails bibliographiques
Auteurs principaux: Hata, Saori, Taniguchi, Miyako, Piao, Yi, Ikeuchi, Takeshi, Fagan, Anne M, Holtzman, David M, Bateman, Randall, Sohrabi, Hamid R, Martins, Ralph N, Gandy, Sam, Urakami, Katsuya, Suzuki, Toshiharu
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422204/
https://ncbi.nlm.nih.gov/pubmed/22534039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-16
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