Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system

BACKGROUND: Aggregatable amyloid β-peptide (Aβ) and non-aggregatable p3-Alcα are metabolic products of the γ-secretase cleavage of amyloid β-protein precursor (APP) and Alcadeinα (Alcα), respectively. Familial AD (FAD) -linked mutations in the presenilin 1 or 2 (PS1 or PS2) component of γ-secretase...

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Detalhes bibliográficos
Main Authors: Konno, Tomoko, Hata, Saori, Hamada, Yukiko, Horikoshi-Sakuraba, Yuko, Nakaya, Tadashi, Saito, Yuhki, Yamamoto, Tohru, Yamamoto, Takayuki, Maeda, Masahiro, Ikeuchi, Takeshi, Gandy, Sam, Akatsu, Hiroyasu, Suzuki, Toshiharu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247855/
https://ncbi.nlm.nih.gov/pubmed/22067061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-76
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