Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase

γ-Cleavage of β-amyloid precursor protein (APP) in the middle of the cell membrane generates amyloid β protein (Aβ), and ϵ-cleavage, ∼10 residues downstream of the γ-cleavage site, releases the APP intracellular domain (AICD). A significant link between generation of Aβ and AICD and failure to detec...

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Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Qi-Takahara, Yue, Morishima-Kawashima, Maho, Tanimura, Yu, Dolios, Georgia, Hirotani, Naoko, Horikoshi, Yuko, Kametani, Fuyuki, Maeda, Masahiro, Saido, Takaomi C., Wang, Rong, Ihara, Yasuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2005
Soggetti:
Neurobiology of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725472/
https://ncbi.nlm.nih.gov/pubmed/15647487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1575-04.2005
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