γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment

Amyloid β protein (Aβ), a pathogenic molecule associated with Alzheimer's disease, is produced by γ-secretase, which cleaves the β-carboxyl terminal fragment (βCTF) of β-amyloid precursor protein in the middle of its transmembrane domain. How the cleavage proceeds within the membrane has long b...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Takami, Mako, Nagashima, Yu, Sano, Yoshihisa, Ishihara, Seiko, Morishima-Kawashima, Maho, Funamoto, Satoru, Ihara, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6665297/
https://ncbi.nlm.nih.gov/pubmed/19828817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2362-09.2009
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