Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cells

door Buettner, Ralf, Mesa, Tania, Vultur, Adina, Lee, Frank, Jove, Richard
Gepubliceerd in 2008

Allosteric Communication Across STAT3 Domains Associated with STAT3 Function and Disease-causing Mutation

door Namanja, Andrew T., Wang, Jianghai, Buettner, Ralf, Colson, Loren, Chen, Yuan
Gepubliceerd in J Mol Biol (2016)

SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells

door Vultur, Adina, Buettner, Ralf, Kowolik, Claudia, Liang, Wei, Smith, David, Boschelli, Frank, Jove, Richard
Gepubliceerd in 2008

Leflunomide Synergizes with Gemcitabine in Growth Inhibition of PC Cells and Impairs c-Myc Signaling through PIM Kinase Targeting

door Buettner, Ralf, Morales, Corey, Wu, Xiwei, Sanchez, James F., Li, Hongzhi, Melstrom, Laleh G., Rosen, Steven T.
Gepubliceerd in Mol Ther Oncolytics (2019)

Glucocorticoid Receptor Expression in Multiple Myeloma Patients is a Predictor of Survival

door Pozhitkov, Alexander, Rosenzweig, Michael, Pichiorri, Flavia, Gunes, Emine G., Buettner, Ralf, Keats, Jonathan J., Rosen, Steven T.
Gepubliceerd in Leuk Lymphoma (2020)

Sorafenib induces growth arrest and apoptosis of human glioblastoma cells via dephosphorylation of STAT3

door Yang, Fan, Brown, Christine, Buettner, Ralf, Hedvat, Michael, Starr, Renate, Scuto, Anna, Schroeder, Anne, Jensen, Michael, Jove, Richard
Gepubliceerd in 2010

Loss of Androgen Receptor Expression Promotes a Stem-Like Cell Phenotype in Prostate Cancer through STAT3 Signaling

door Schroeder, Anne, Herrmann, Andreas, Cherryholmes, Gregory, Kowolik, Claudia, Buettner, Ralf, Pal, Sumanta, Yu, Hua, Müller-Newen, Gerhard, Jove, Richard
Gepubliceerd in Cancer Res (2013)

Increasing Antitumor Activity of JAK Inhibitor by Simultaneous Blocking Multiple Survival Signaling Pathways in Human Ovarian Cancer

door Wen, Wei, Han, Ernest S., Dellinger, Thanh H., Wu, Jun, Guo, Yuming, Buettner, Ralf, Horne, David A., Jove, Richard, Yim, John H.
Gepubliceerd in Transl Oncol (2019)

A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling

door Liu, Lucy, Kritsanida, Marina, Magiatis, Prokopios, Gaboriaud, Nicolas, Wang, Yan, Wu, Jun, Buettner, Ralf, Yang, Fan, Nam, Sangkil, Skaltsounis, Leandros, Jove, Richard
Gepubliceerd in 2012

Spirooxindole Derivative SOID-8 Induces Apoptosis Associated with Inhibition of JAK2/STAT3 Signaling in Melanoma Cells

door Tian, Yan, Nam, Sangkil, Liu, Lucy, Yakushijin, Fumiko, Yakushijin, Kenichi, Buettner, Ralf, Liang, Wei, Yang, Fan, Ma, Yuelong, Horne, David, Jove, Richard
Gepubliceerd in 2012

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

door Nam, Sangkil, Buettner, Ralf, Turkson, James, Kim, Donghwa, Cheng, Jin Q., Muehlbeyer, Stephan, Hippe, Frankie, Vatter, Sandra, Merz, Karl-Heinz, Eisenbrand, Gerhard, Jove, Richard
Gepubliceerd in 2005

Systemic delivery of TLR9-activating/STAT3-blocking oligonucleotides induces leukemia regression

door Zhang, Qifang, Md Sakib Hossain, Dewan, Nechaev, Sergey, Buettner, Ralf, Swiderski, Piotr, Jozwiak, Agnieszka, Forman, Stephen J, Bhatia, Ravi, Kuo, Ya-Huei, Kortylewski, Marcin
Gepubliceerd in J Immunother Cancer (2014)

Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer

door Wen, Wei, Wu, Jun, Liu, Lucy, Tian, Yan, Buettner, Ralf, Hsieh, Meng-Yin, Horne, David, Dellinger, Thanh H, Han, Ernest S, Jove, Richard, Yim, John H
Gepubliceerd in Mol Cancer (2015)

CRITICAL ROLE OF STAT3 IN IL-6-MEDIATED DRUG RESISTANCE IN HUMAN NEUROBLASTOMA

door Ara, Tasnim, Nakata, Rie, Sheard, Michael A., Shimada, Hiroyuki, Buettner, Ralf, Groshen, Susan G., Ji, Lingyun, Yu, Hua, Jove, Richard, Seeger, Robert C., DeClerck, Yves A.
Gepubliceerd in 2013

Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor

door Yang, Fan, Jove, Veronica, Chang, Shirley, Hedvat, Michael, Liu, Lucy, Buettner, Ralf, Tian, Yan, Scuto, Anna, Wen, Wei, Yip, M.L. Richard, Van Meter, Timothy, Yen, Yun, Jove, Richard
Gepubliceerd in 2012

Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine

door Buettner, Ralf, Nguyen, Le Xuan Truong, Morales, Corey, Chen, Min-Hsuan, Wu, Xiwei, Chen, Lisa S., Hoang, Dinh Hoa, Hernandez Vargas, Servando, Pullarkat, Vinod, Gandhi, Varsha, Marcucci, Guido, Rosen, Steven T.
Gepubliceerd in J Hematol Oncol (2021)

Sorafenib inhibits STAT3 signaling associated with growth arrest and apoptosis of medulloblastomas

door Yang, Fan, Van Meter, Timothy E., Buettner, Ralf, Hedvat, Michael, Liang, Wei, Kowolik, Claudia M., Mepani, Nilesh, Mirosevich, Janni, Nam, Sangkil, Chen, Mike Y., Tye, Gary, Kirschbaum, Mark, Jove, Richard
Gepubliceerd in 2008

Inhibition of de novo pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer

door Phan, Thuy, Nguyen, Vu H., Buettner, Ralf, Morales, Corey, Yang, Lifeng, Wong, Paul, Tsai, Weiman, Salazar, Marcela d'Alincourt, Gil, Ziv, Diamond, Don J, Rabinowitz, Joshua D., Rosen, Steven, Melstrom, Laleh G.
Gepubliceerd in Int J Biol Sci (2021)

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia

door Zhang, Qifang, Hossain, Dewan Md Sakib, Duttagupta, Priyanka, Moreira, Dayson, Zhao, Xingli, Won, Haejung, Buettner, Ralf, Nechaev, Sergey, Majka, Marcin, Zhang, Bin, Cai, Qi, Swiderski, Piotr, Kuo, Ya-Huei, Forman, Stephen, Marcucci, Guido, Kortylewski, Marcin
Gepubliceerd in Blood (2016)

Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer

door Wen, Wei, Liang, Wei, Wu, Jun, Kowolik, Claudia M., Buettner, Ralf, Scuto, Anna, Hsieh, Meng-Yin, Hong, Hao, Brown, Christine E., Forman, Stephen J., Horne, David, Morgan, Robert, Wakabayashi, Mark, Dellinger, Thanh H., Han, Ernest S., Yim, John H., Jove, Richard
Gepubliceerd in Mol Cancer Ther (2014)