Leflunomide Synergizes with Gemcitabine in Growth Inhibition of PC Cells and Impairs c-Myc Signaling through PIM Kinase Targeting

The immunosuppressive agent leflunomide has been used in the treatment of over 300,000 patients with rheumatoid arthritis. Its active metabolite, teriflunomide (Ter), directly inhibits dihydroorotate dehydrogenase (DHODH), an enzyme involved in nucleoside synthesis. We report that Ter not only shows...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Buettner, Ralf, Morales, Corey, Wu, Xiwei, Sanchez, James F., Li, Hongzhi, Melstrom, Laleh G., Rosen, Steven T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562366/
https://ncbi.nlm.nih.gov/pubmed/31211245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2019.04.006
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