Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting

Teriflunomide, the active metabolite of leflunomide, downregulates c-Myc expression through inhibition of PIM kinases. Leflunomide together with lenalidomide significantly extended survival in an in vivo MM model.

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Buettner, Ralf, Morales, Corey, Caserta, Enrico, Troadec, Estelle, Gunes, Emine G., Viola, Domenico, Khalife, Jihane, Li, Hongzhi, Keats, Jonathan J., Christofferson, Austin, Wu, Xiwei, Synold, Timothy W., Palmer, Joycelynne, Sanchez, James F., Pozhitkov, Alexander, Vaidehi, Nagarajan, Marcucci, Guido, Krishnan, Amrita, Rosenzweig, Michael A., Pichiorri, Flavia, Rosen, Steven T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Stimulus Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457239/
https://ncbi.nlm.nih.gov/pubmed/30940637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018027227
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