Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting

Teriflunomide, the active metabolite of leflunomide, downregulates c-Myc expression through inhibition of PIM kinases. Leflunomide together with lenalidomide significantly extended survival in an in vivo MM model.

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Blood Adv
मुख्य लेखकों: Buettner, Ralf, Morales, Corey, Caserta, Enrico, Troadec, Estelle, Gunes, Emine G., Viola, Domenico, Khalife, Jihane, Li, Hongzhi, Keats, Jonathan J., Christofferson, Austin, Wu, Xiwei, Synold, Timothy W., Palmer, Joycelynne, Sanchez, James F., Pozhitkov, Alexander, Vaidehi, Nagarajan, Marcucci, Guido, Krishnan, Amrita, Rosenzweig, Michael A., Pichiorri, Flavia, Rosen, Steven T.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Hematology 2019
विषय:
Stimulus Report
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457239/
https://ncbi.nlm.nih.gov/pubmed/30940637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018027227
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