Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting

Teriflunomide, the active metabolite of leflunomide, downregulates c-Myc expression through inhibition of PIM kinases. Leflunomide together with lenalidomide significantly extended survival in an in vivo MM model.

Na minha lista:
Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Buettner, Ralf, Morales, Corey, Caserta, Enrico, Troadec, Estelle, Gunes, Emine G., Viola, Domenico, Khalife, Jihane, Li, Hongzhi, Keats, Jonathan J., Christofferson, Austin, Wu, Xiwei, Synold, Timothy W., Palmer, Joycelynne, Sanchez, James F., Pozhitkov, Alexander, Vaidehi, Nagarajan, Marcucci, Guido, Krishnan, Amrita, Rosenzweig, Michael A., Pichiorri, Flavia, Rosen, Steven T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Stimulus Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457239/
https://ncbi.nlm.nih.gov/pubmed/30940637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018027227
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker