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Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma
The oncogenic PIM1 kinase has been implicated as a cofactor for c-MYC in prostate carcinogenesis. Here we show that in human prostate tumors, coexpression of c-MYC and PIM1 is associated with higher Gleason grades. Using a tissue recombination model coupled with lentiviral-mediated gene transfer we...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2861731/ https://ncbi.nlm.nih.gov/pubmed/20140016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.10 |
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