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Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells
PIM1 kinase and MYC are commonly co-expressed in human prostate cancer and synergize to induce rapidly progressing prostate cancer in mouse models. Deficiency of the Pim kinase genes is well tolerated in vivo, suggesting that PIM1 inhibition might offer an attractive therapeutic modality for prostat...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3223544/ https://ncbi.nlm.nih.gov/pubmed/21860423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.371 |
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