PIM Kinase Inhibitor AZD1208 for Treatment of MYC-Driven Prostate Cancer

BACKGROUND: PIM1 kinase is coexpressed with c-MYC in human prostate cancers (PCs) and dramatically enhances c-MYC-induced tumorigenicity. Here we examine the effects of a novel oral PIM inhibitor, AZD1208, on prostate tumorigenesis and recurrence. METHODS: A mouse c-MYC/Pim1-transduced tissue recomb...

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Udgivet i:J Natl Cancer Inst
Main Authors: Kirschner, Austin N., Wang, Jie, van der Meer, Riet, Anderson, Philip D., Franco-Coronel, Omar E., Kushner, Max H., Everett, Joel H., Hameed, Omar, Keeton, Erika K., Ahdesmaki, Miika, Grosskurth, Shaun E., Huszar, Dennis, Abdulkadir, Sarki A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326311/
https://ncbi.nlm.nih.gov/pubmed/25505253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju407
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