Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas

BACKGROUND: A promising therapeutic approach for aggressive B-cell Non-Hodgkin lymphoma (NHL), including diffuse large B-cell lymphoma (DLBCL), and Burkitt lymphoma (BL) is to target kinases involved in signal transduction and gene regulation. PIM1/2 serine/threonine kinases are highly expressed in...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Kreuz, S., Holmes, K. B., Tooze, R. M., Lefevre, P. F.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672512/
https://ncbi.nlm.nih.gov/pubmed/26643319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0477-z
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