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Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells
PIM1 kinase and MYC are commonly co-expressed in human prostate cancer and synergize to induce rapidly progressing prostate cancer in mouse models. Deficiency of the Pim kinase genes is well tolerated in vivo, suggesting that PIM1 inhibition might offer an attractive therapeutic modality for prostat...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3223544/ https://ncbi.nlm.nih.gov/pubmed/21860423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.371 |
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