Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia

Targeting oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) in acute myeloid leukemia (AML) can reduce blast survival and tumor immune evasion. Decoy oligodeoxynucleotides (dODNs), which comprise STAT3-specific DNA sequences are competitive inhibition of STAT3...

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Vydáno v:Blood
Hlavní autoři: Zhang, Qifang, Hossain, Dewan Md Sakib, Duttagupta, Priyanka, Moreira, Dayson, Zhao, Xingli, Won, Haejung, Buettner, Ralf, Nechaev, Sergey, Majka, Marcin, Zhang, Bin, Cai, Qi, Swiderski, Piotr, Kuo, Ya-Huei, Forman, Stephen, Marcucci, Guido, Kortylewski, Marcin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2016
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817311/
https://ncbi.nlm.nih.gov/pubmed/26796361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-08-665604
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