Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor

Medulloblastoma is the most common brain tumor in children. Here, we report that bortezomib, a proteasome inhibitor, induced apoptosis and inhibited cell proliferation in two established cell lines and a primary culture of human medulloblastomas. Bortezomib increased the release of cytochrome c to c...

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Autors principals: Yang, Fan, Jove, Veronica, Chang, Shirley, Hedvat, Michael, Liu, Lucy, Buettner, Ralf, Tian, Yan, Scuto, Anna, Wen, Wei, Yip, M.L. Richard, Van Meter, Timothy, Yen, Yun, Jove, Richard
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341212/
https://ncbi.nlm.nih.gov/pubmed/22313636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.19239
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