ABT-737 synergizes with Bortezomib to kill melanoma cells

The BH3 mimetic ABT-737 is a potent inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L), and Bcl-w. The Bcl-2 family modulates sensitivity to anticancer drugs in many cancers, including melanomas. In this study, we examined whether ABT-737 is effective in killing melanoma cells either alone or...

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Autori principali: Reuland, Steven N., Goldstein, Nathaniel B., Partyka, Katie A., Smith, Shilo, Luo, Yuchun, Fujita, Mayumi, Gonzalez, Rene, Lewis, Karl, Norris, David A., Shellman, Yiqun G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507205/
https://ncbi.nlm.nih.gov/pubmed/23213401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.2011035
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