Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer

BACKGROUND: The EGFR signaling pathway is frequently activated in human ovarian cancer and associated with poor prognosis. However, inhibition of EGFR signaling in patients with recurrent ovarian cancer has been disappointing. It remains to be addressed whether ovarian cancer patients could benefit...

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Dettagli Bibliografici
Pubblicato in:Mol Cancer
Autori principali: Wen, Wei, Wu, Jun, Liu, Lucy, Tian, Yan, Buettner, Ralf, Hsieh, Meng-Yin, Horne, David, Dellinger, Thanh H, Han, Ernest S, Jove, Richard, Yim, John H
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437681/
https://ncbi.nlm.nih.gov/pubmed/25928246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0366-5
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