USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria. We present the characterisation of an N-cyano pyrrolidine compound, FT3967385, with high selectivity for USP30. We demonstrate that ubiquitylation of TOM20, a component of the outer mitochond...

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Dettagli Bibliografici
Pubblicato in:Life Sci Alliance
Autori principali: Rusilowicz-Jones, Emma V, Jardine, Jane, Kallinos, Andreas, Pinto-Fernandez, Adan, Guenther, Franziska, Giurrandino, Mariacarmela, Barone, Francesco G, McCarron, Katy, Burke, Christopher J, Murad, Alejandro, Martinez, Aitor, Marcassa, Elena, Gersch, Malte, Buckmelter, Alexandre J, Kayser-Bricker, Katherine J, Lamoliatte, Frederic, Gajbhiye, Akshada, Davis, Simon, Scott, Hannah C, Murphy, Emma, England, Katherine, Mortiboys, Heather, Komander, David, Trost, Matthias, Kessler, Benedikt M, Ioannidis, Stephanos, Ahlijanian, Michael K, Urbé, Sylvie, Clague, Michael J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Life Science Alliance LLC 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362391/
https://ncbi.nlm.nih.gov/pubmed/32636217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000768
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